Aller au contenu principal
  • À propos d'ELGA
    • À propos d'ELGA
    • Eau ultra-pure
    • Technologies de purification
    • Impuretés dans l'eau
    • Guides et livres blancs
    • Partenaires agréés
    • Durabilité
    • Réduire les risques cliniques
    • Carrières
    • Événements
    • HPLC dans le secteur pharmaceutique
    • Pureté de l'eau pour la HPLC
  • Blog
    • Analytical Chemistry
    • Clinical & Pharma
    • Cool Science
    • Environment and sustainability
    • Life in the lab
    • Purelab product design
    • Science of the future
    • Water Purity
    • Water in the lab
  • Contact
  • English
  • Deutsch
  • Español
  • Italiano
  • Português
  • 日本語
  • 中文
Accueil ELGA LabWater
  • Produits
  • Applications
  • Études de cas
  • Assistance
  • Produits
    • PURELAB
    • CENTRA
    • MEDICA
    • BIOPURE
    • Gamme complète des produits ELGA
  • Applications
  • Études de cas
    • Découvrir les secrets de l'Antarctique à l'aide d'eau ultra-pure
    • Abbott Diagnostics opte pour les systèmes ELGA MEDICA en Asie du Sud
    • Ca’Foscari University- A New Method for Investigating Environmental Tracers in Ice
    • Ca’Foscari University- Investigating Contaminants in Antarctic Ice
    • DASA : la plus grande société de diagnostic médical au Brésil
    • ELGA aide les laboratoires d'immuno-sérologie à maximiser la disponibilité
    • Importance de l'eau ultra-pure de type 1+ pour la mise au point de médicaments génériques
    • MEDICA® Pro sélectionné pour les analyseurs Siemens ADVIA® à l'hôpital général de la ville
    • Optimale Wasserqualität für mikrobiologische Forschung und Lehre
    • PURELAB® flex : un système de formation idéal pour la méthode de recherche actuelle
    • Sichere Reinstwasserversorgung für präzise Produkttests
    • Zentrale Reinstwasser-Aufbereitung für Analyser
  • Assistance
    • Assistance et services
    • Aménagement du laboratoire
    • Enregistrer un produit
    • Register Your Product (USA & Canada Only)
  • Produits
    • PURELAB
      • PURELAB Chorus 1 Complet
      • PURELAB® Chorus 1
      • PURELAB Chorus 2+
      • PURELAB® Chorus 2
      • PURELAB® Chorus 3
      • PURELAB® flex 1 & 2
      • PURELAB® flex 3 et 4
    • CENTRA
      • CENTRA® 60/120
      • CENTRA® RDS
      • CENTRA® R200
    • MEDICA
      • MEDICA® 7/15
      • MEDICA® EDI 15/30
      • MEDICA® Pro EDI 60/120
      • MEDICA® Pro-LPS
      • MEDICA® Pro-R et Pro-RE
      • MEDICA® R200
    • BIOPURE
      • BIOPURE 7/15
      • BIOPURE 60/120
      • BIOPURE 200/300/600
    • Gamme complète des produits ELGA
      • PURELAB® Classic
  • Applications
  • Études de cas
    • Découvrir les secrets de l'Antarctique à l'aide d'eau ultra-pure
    • Abbott Diagnostics opte pour les systèmes ELGA MEDICA en Asie du Sud
    • Ca’Foscari University- A New Method for Investigating Environmental Tracers in Ice
    • Ca’Foscari University- Investigating Contaminants in Antarctic Ice
    • DASA : la plus grande société de diagnostic médical au Brésil
    • ELGA aide les laboratoires d'immuno-sérologie à maximiser la disponibilité
    • Importance de l'eau ultra-pure de type 1+ pour la mise au point de médicaments génériques
    • MEDICA® Pro sélectionné pour les analyseurs Siemens ADVIA® à l'hôpital général de la ville
    • Optimale Wasserqualität für mikrobiologische Forschung und Lehre
    • PURELAB® flex : un système de formation idéal pour la méthode de recherche actuelle
    • Sichere Reinstwasserversorgung für präzise Produkttests
    • Zentrale Reinstwasser-Aufbereitung für Analyser
  • Assistance
    • Assistance et services
    • Aménagement du laboratoire
    • Enregistrer un produit
    • Register Your Product (USA & Canada Only)
  • English
  • Deutsch
  • Español
  • Italiano
  • Português
  • 日本語
  • 中文
  • Politique relative à la confidentialité
  • Conditions générales
  • Conformité juridique mondiale
  • Brevets
  • Impressum
  • Accueil
  • Node
  • Photodynamic Therapy: A Promising Alternative For Treating Blood Infections?
Clinical & Pharma
Science of the Future

Photodynamic Therapy: A Promising Alternative For Treating Blood Infections?

16 fév 2020
- by Dr Alison Halliday

blood infection

With antibiotic resistance one of the biggest health challenges facing our world today, the hunt is on for effective alternatives. In a new study, researchers develop a unique experimental system to test the effectiveness of photodynamic therapies for eradicating bloodstream infections.

Photodynamic therapy (PDT) incorporates the use of photosensitive drugs that are activated using a light source. Already used to successfully treat some eye and skin conditions as well as certain types of cancer, scientists are now exploring its potential for treating bacterial infections.

Previously, PDT was limited to treating local or superficial applications – meaning that it was unsuitable for systemic bacterial infections, such as sepsis of the blood. But recently, researchers have demonstrated its potential effectiveness for treating such illnesses – although this currently involves disinfection of the patient’s blood whilst outside of the body.

As the vast majority of clinically-approved photosensitive agents are delivered intravenously, there is a need to develop new methods that can work within the patient’s bloodstream.

A New Dynamic Circulation Model 

Most PDT experimental testing systems currently available for researchers involve static conditions, which are not physiologically-relevant for bloodstream infections.
In a first-of-its-kind approach, a team of scientists in Germany have now made use of a unique dynamic circulation model to facilitate antibacterial PDT under flow conditions created to mimic the bloodstream.1 Designed with the human circulatory system in mind, the researchers simulated the heart with a pump, the blood vessels using silicone tubing corresponding to a mid-sized vein – and achieved a constant body temperature by submerging most of the tubing within a water bath.

Curcumin-Loaded Nanoparticles

To test their model, the researchers prepared PLGA2 nanoparticles loaded with the naturally-occurring photosensitiser, curcumin – which, once activated with light of a specific wavelength, generates reactive oxygen species that can kill bacteria.

For the steps involved in the preparation and characterisation of the curcumin-loaded nanoparticles, the researchers used ultrapure water obtained from a ELGA PURELAB® Flex 4 laboratory water purification system – minimising the risk of introducing any contaminants that could affect the outcome of their experiments.

Bacterial-Killing Effects of Locally Administered PDT

The researchers added a suspension of bacteria and nanoparticles into their experimental circulation system, using the pump to achieve an even distribution. After a short incubation period, they administered different doses of irradiation using a laser light that they incorporated into the silicone tubing. Their results showed that the local administration of PDT using nanoparticles loaded with curcumin led to a significant reduction in bacterial viability.

This new circulation model will now enable researchers to simulate the physiological environment of the venous circulatory system for testing new photosensitizers under flow conditions – paving the way for the development of new PDT strategies for treating bloodstream infections that could help to decrease our reliance on antibiotics.

Why Choose ELGA LabWater?

We are the LabWater Specialists, for over 80 years we have been working with scientists to guarantee pure and ultrapure water for their research and lab work. Laboratories around the world trust our water purification systems to help their researchers to achieve accurate, reliable, quality results.

 

References:

  1. Raschpichler M. et al. In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections. Photochem. Photobiol. Sci., 2019, Advance Article, DOI: 10.1039/C8PP00267C
  2. Poly(D,L-lactide-coglycolide)

 

Dr Alison Halliday
After completing an undergraduate degree in Biochemistry & Genetics at Sheffield University, Alison was awarded a PhD in Human Molecular Genetics at the University of Newcastle. She carried out five years as a Senior Postdoctoral Research Fellow at UCL, investigating the genes involved in childhood obesity syndrome. Moving into science communications, she spent ten years at Cancer Research UK engaging the public about the charity’s work. She now specialises in writing about research across the life sciences, medicine and health.

 

  • Enquiry
  • Obtenir un devis
  • Réservez une démo
  • Trouver un partenaire approuvé

Enquiry

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Obtenir un devis

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Réservez une démo

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Call us

Can't find what you are looking for?

Support Number
+44 (0)20 3567 7300
United Kingdom Sales
+44 (0)1628 879 704
United States of America Sales
+1 877-315-3542
France Sales
+33 1 40 83 65 00
China Sales
+86 400-616-8882

 

Siège social ELGA LabWater

Lane End Business Park
Lane End, High Wycombe
HP14
3BY Royaume-Uni
T : +44 (0) 203 567 7300 - Fax
 : +44 (0) 203 567 7205

Les spécialistes de l'eau ultra-pure

  • Assistance et services
  • Événements

Études de cas

  • Diagnostics Abbott
  • Diagnostics médicaux DASA
  • Institut médical NeoDIN
  • Fondation North Staffordshire NHS Trust
  • Lycée professionnel d'Olsberg

Ressources

  • En savoir plus sur l'eau ultra-pure
  • Guides et livres blancs
  • Technologies de purification
  • Applications
  • Impuretés dans l'eau

Blogs

  • Latest Blog
  • Water Purity - Different Types of Pure Water
  • What is Clinical Laboratory Reagent Water (CLSI)?
  • What is Total Organic Carbon (TOC)?
  • Langue
    • Deutsch
    • English
    • Español
    • Français
    • Italiano
    • Português
    • 日本語
    • 中文
  • Autres sites Veolia
    • Veolia
    • Veolia Fondation
    • Veolia Water Technologies

© VWS (UK) Ltd. exerçant sous le nom ELGA LabWater.2021-Tous les droits sont réservés.
ELGA est la marque mondiale d'eau de laboratoire de Veolia.

  • Politique relative à la confidentialité
  • Conditions générales
  • Conformité juridique mondiale
  • Brevets
  • Impressum
Elga Veolia
TOP

© 2017 ELGA Veolia